Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 455, Issue C, Pages 4-12Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.01.042
Keywords
Immunosenescence; Autoimmune diseases; Metabolism; Aging; Fasting; Fasting mimicking diet
Categories
Funding
- NIA NIH HHS [R01 AG052558] Funding Source: Medline
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Complex and coordinated signals are necessary to initiate and sustain the activation, proliferation, and differentiation of lymphocytes. These signals, which are known to determine T-cell fate and function, also depend on the metabolic state of the organism. Recent studies indicate that both the type and levels of nutrients can influence the generation, survival and function of lymphocytes and therefore can affect several autoimmune diseases. Here, we review the dysregulation of lymphocytes during autoimmunity and aging, the mechanisms associated with loss of immune function, and how fasting mimicking diets and other dietary interventions affect autoimmunity and immunosenescence. (C) 2017 Elsevier B.V. All rights reserved.
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