Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 441, Issue C, Pages 176-184Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.08.050
Keywords
Adrenal cancer; Steroidogenesis; Mitochondria associated membrane MAM; Apoptosis
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Funding
- Institut National Du Cancer [2008-045]
- FP7 ENS@T-Cancer [259735]
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Steroidogenesis is a multistep process where interorganelle communications between the endoplasmic reticulum and mitochondria are critical. These intimate interactions physically occur through the Mitochondria-Associated ER membranes called MAMs. MAMs play important roles in mitochondrial morphology and in many cellular functions ranging from lipid metabolism, to calcium signaling and apoptosis together with a critical effect on steroidogenesis. Moreover, our recent characterization of new MAM resident proteins in adrenocortical cells extends the function of MAM in the mechanism of resistance of cancer cells to apoptotic stimuli and offers new perspectives in targeted therapeutic approaches for adrenocortical tumorigenesis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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