Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 441, Issue C, Pages 99-107Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.10.008
Keywords
5-HT; Cortisol; Calcium current; cAMP; Adrenocortical cells; Protein kinase A
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Funding
- Institut National de la Sante et de la Recherche Medicale Unite 982
- Centre Hospitalier Universitaire de Rouen
- Conseil Regional de Normandie
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In human adrenal, serotonin (5-HT), produced by mast cells located in zona glomerulosa, stimulates production of corticosteroids through a paracrine mechanism involving the 5-HT receptor type 4 (5-HT4). The aim of the present study was to investigate the transduction mechanisms associated with activation of 5-HT4 receptors in human adrenocortical cells. Our results show that 5-HT4 receptors are present in the outer adrenal cortex, both in glomerulosa and fasciculata zonae. In the zona glomerulosa. 5-HT4 receptor was detected both in immunopositive and immunonegative cells for 11 beta-hydroxylase, an enzyme involved in cortisol synthesis. The data demonstrate that 5-HT4 receptors are positively coupled to adenylyl cyclases and cAMP-dependent protein kinases (PICA). The activation of the cAMP-PICA pathway is associated with calcium influx through T-type calcium channels. Both the adenylyl cyclase/PKA pathway and the calcium influx are involved in 5-HT-induced cortisol secretion. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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