Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 456, Issue C, Pages 51-61Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.01.021
Keywords
microRNAs; Pituitary tumors
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Funding
- Institut National de la Sante et de la Recherche Medicale
- University of Lyon
- Ligue Contre le Cancer
- Region RhoneAlpes (France)
- Programme Hospitalier de Recherche Clinique National (PHRC) [27-43]
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Since the presence of microRNAs was first observed in normal pituitary, the majority of scientific publications addressing their role and the function of microRNAs in the pituitary have been based on pituitary tumor studies. In this review, we briefly describe the involvement of microRNAs in the synthesis of pituitary hormones and we present a comprehensive inventory of microRNA suppressors and inducers of pituitary tumors. Finally, we summarize the functional role of microRNAs in tumorigenesis, progression and aggressiveness of pituitary tumors, mechanisms contributing to the regulation (transcription factors, genomic modifications or epigenetic) or modulation (pharmacological treatment) of microRNAs in these tumors, and the interest of thoroughly studying the expression of miRNAs in body fluids. (C) 2017 Elsevier B.V. All rights reserved.
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