Journal
JOURNAL OF PHARMACEUTICAL ANALYSIS
Volume 9, Issue 1, Pages 62-69Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpha.2018.11.005
Keywords
Paracetamol; Neodymium (III) Oxide; Single-walled carbon nanotubes; Pharmaceutical dosage
Categories
Funding
- Universidad de los Andes
- Universidad de Ibague [18-541-INT]
- COLCIENCIAS [130774559056]
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This study presents for the first time a new composite of carbon paste (CP), single-walled carbon nanotubes (SWCNTs) and Nd2O3 (Nd-ox). This versatile composite (Nd-ox-SWCNT/CPE) was applied to the oxidation of paracetamol (PCM). The newly formed surface was characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The results showed greater conductivity and a higher surface area for the composite than those of the carbon paste alone. Moreover, the anodic peak currents for PCM increased from 1.6 to 3.6 mu A with CPE and Nd-ox-SWCNT/CPE, indicating an increase of nearly 51.0% for the anodic peak current. On the other hand, the anodic peak potentials shifted from 0.67 to 0.57 V. The detection limits were 0.05 mu mol/L with Nd-ox-SWCNT/CPE and 0.50 mu mol/L with SWCNT/CPE. The relative standard deviations (RSDs) were 1.5% (n = 7). The accuracy and interference of the methods were evaluated with a urine chemistry control spiked with known quantities of PCM, uric acid, dopamine, ascorbic acid, caffeine, acetylsalicylic acid, tartrazine, sunset yellow, allure red, rutin, morin and metal ions. Finally, the novelty and usefulness of the composite were evaluated to quantify PCM in pharmaceutical dosage forms such as tablets, powders and syrups for children. (C) 2018 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.
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