Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 443, Issue C, Pages 155-162Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.01.017
Keywords
Polycystic Ovary Syndrome; Microparticles; Platelets; Leukocytes; Endothelial cells; Tissue factor
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq - 449703/2014-2]
- Coordenacao de Aperfeicoamento de Pessoal do Ensino Superior (CAPES)
- Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG) [FAPEMIG - PPM-00530-13]
- CNPq
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Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the micro particles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50). PCOS women presented increased total MPs, PMPs, LMPs and EMPs levels when compared to control group (all p < 0.05). TFMPs was similar between the groups (p = 0.379). In conclusion, these MPs populations could be useful biomarkers for association with thrombosis and cardiovascular disease in PCOS women. (C) 2017 Elsevier B.V. All rights reserved.
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