Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 4, Pages 807-812Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob02533a
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Funding
- Natural Science Foundation of Zhejiang Province [LY17B020010]
- International Cooperation Project 948 [2014-4-29]
- National Science and Technology Support Project [2015BAD14B0305]
- National Natural Science Foundation of China [21306172]
- Science and Technology Research Program of Zhejiang Province [2014C32094]
- Natural Science Foundation of Zhejiang University of Technology [116004029]
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A fast and green protocol for the Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor was developed. In contrast with existing methods, this method is simple (35 min), uses mild reaction conditions (45 degrees C) and is environmentally friendly. This enzymatic Michael addition performed in continuous flow microreactors is an innovation that may open up the use of enzymatic microreactors in imidazole analogue biotransformations.
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