Journal
ISCIENCE
Volume 11, Issue -, Pages 466-+Publisher
CELL PRESS
DOI: 10.1016/j.isci.2018.12.034
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Funding
- Israel Science Foundation (Moked grant)
- GIF Foundation
- ICRF professorship grant
- ISF Israel-China grant
- Ministry of Science and Technology grant
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Long, non-coding RNAs (IncRNAs) are involved in the regulation of many cellular processes. The IncRNA IFNG-AS1 was found to strongly influence the responses to several pathogens in mice by increasing interferon gamma (IFN gamma) secretion. Studies have looked at IFNG-AS1 in T cells, yet IFNG-AS1 function in natural killer cells (NKs), an important source of IFN gamma, remains unknown. Here, we show a previously undescribed sequence of IFNG-AS1 and report that it may be more abundant in cells than previously thought. Using primary human NKs and an NK line with IFNG-AS1 over expression, we show that IFNG-AS1 is quickly induced upon NK cell activation, and that IFNG-AS1 overexpression leads to increased IFN gamma secretion. Taken together, our work expands IFNG-AS1's activity to the innate arm of the type I immune response, helping to explain its notable effect in animal models of disease.
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