Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 6, Pages 755-758Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc08708c
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Funding
- Thousand Youth Talents Plan, NSFC [21672145, 51733007]
- Shuguang program from SEDFSMEC [16SG10]
- STCSM [17JC1403700]
- Innovation Fund from the Joint Research Center for Precision Medicine of Shanghai Jiao Tong University [IFPM016A002]
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An efficient and convenient copper-mediated method has been developed to achieve direct cascade C-H/N-H annulation to synthesize 2-quinolinones from electron-deficient acrylamides and arynes. This method highlights an emerging but simple strategy to transform inert C-H bonds into versatile functional groups in organic synthesis to provide a new method of synthesizing 2-quinolinones efficiently. Mechanistic investigations by experimental and density functional theory (DFT) studies suggest that an organometallic C-H activation via a Cu(III) intermediate is likely to be involved in the reaction.
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