Journal
JOURNAL OF CANCER
Volume 10, Issue 4, Pages 821-828Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.27899
Keywords
KRAS; BRAF; PIK3CA; Mutation; Gastric cancer
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Funding
- National Key Research and Development Program of China [2017YFC1308800]
- National Natural Science Foundation of China [81201545, 81201581]
- Young Teacher Training Program of Sun Yat-sen University [14YKPY31]
- Science and Technology Planning Project of Guangdong Province [2015B010129008, 2012B031800355]
- 985 Project of Sun Yat-sen University [4202037]
- National Basic Research Program of China [2015CB554001]
- China Scholarship Council [201706385049]
- frontier and key technology innovation project of Guangdong Province [2014B010118003]
- National Key Clinical Discipline
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This study aims to investigate the molecular characteristics of Chinese gastric cancer patients. In our study, the KRAS, BRAF, and PIK3CA mutation status of 485 GC patients were analyzed by Sanger sequencing. Kaplan-Meier analysis was used to plot survival curves according to different genotypes. The results show that the frequency of KRAS, BRAF and PIK3CA mutations were 4.1%, 1.2% and 3.5%, respectively. BRAF mutations were significantly concentrated in stage III and IV gastric cancer (P=0.009). KRAS G12V mutation carriers have much shorter OS than other mutation carriers and wild-type group patients (P=0.013). In conclusion, only the KRAS G12V mutation has an adverse effect on patient survival.
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