Journal
BIOENGINEERING & TRANSLATIONAL MEDICINE
Volume 4, Issue 1, Pages 5-16Publisher
WILEY
DOI: 10.1002/btm2.10122
Keywords
clinical trials; nanocrystals; nanomedicine; nanoparticles; nanotherapeutics; translational medicine
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Poorly soluble small molecules typically pose translational hurdles owing to their low solubility, low bioavailability, and formulation challenges. Nanocrystallization is a versatile method for salvaging poorly soluble drugs with the added benefit of a carrier-free delivery system. In this review, we provide a comprehensive analysis of nanocrystals with emphasis on their clinical translation. Additionally, the review sheds light on clinically approved nanocrystal drug products as well as those in development.
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