Journal
MITOCHONDRION
Volume 34, Issue -, Pages 135-140Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2017.03.005
Keywords
Uncoupling proteins; Mitochondrial dysfunction; Metabolic disorder; Cancer; Obesity; Diabetes
Categories
Funding
- NCI NIH HHS [R21 CA164218] Funding Source: Medline
Ask authors/readers for more resources
Mitochondria are fascinating organelles involved in various cellular-metabolic activities that are integral for mammalian development. Although they perform diverse, yet interconnected functions, mitochondria are remarkably regulated by complex signaling networks. Therefore, it is not surprising that mitochondrial dysfunction is involved in plethora of diseases, including neurodegenerative and metabolic disorders. One of the many factors that lead to mitochondrial-associated metabolic diseases is the uncoupling protein-2, a family of mitochondrial anion proteins present in the inner mitochondrial membrane. Since their discovery, uncoupling proteins have attracted considerable attention due to their involvement in mitochondrial-mediated oxidative stress and energy metabolism. This review attempts to provide a summary of recent developments in the field of uncoupling protein 2 relating to mitochondrial associated metabolic diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available