Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 17, Issue 8, Pages 683-692Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557515666151016124957
Keywords
Application of fluorine; anticancer; antimicrobial; anti-inflammatory; antivirus activity; drug design; importance of fluorinated compounds
Categories
Funding
- National Natural Science Foundation of China [41276167, 41506169, 41306157]
- China Postdoctoral Science Foundation [2015T80755]
- Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02-06]
- Key research and development project of Shandong province [2015GSF115029]
- Science and Technology Development Program of Qingdao Shinan District [2012-5-007-SW, 2014-14-005-SW]
- Key Research Program of Frontier Sciences, CAS [QYZDB-SSW-DQC014]
- Qingdao National Laboratory for Marine Science and Technology
- National Program for Support of Top-notch Young Professionals
- Taishan scholar Youth Project of Shandong province
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Background: The widespread application of fluorine in drug design benefits from distinctive properties. Incorporation of fluorine can positively modulate certain pharmacokinetics properties, including lipophilicity, eletrophilicity, metabolic stability, chemical stability, et al., which were of interest to medicinal chemists. Herein, fluorinated compounds, which have been designed and evaluated for anticancer, antimicrobial, anti-inflammatory and antivirus activity, et al. during the last 6 years (2010-2015) are summarized. Conclusion: The emphasis is to highlight the importance of fluorinated compounds and the changes in the properties of compounds when introducing fluorine atom.
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