Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 17, Issue 16, Pages 1515-1536Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557516666160624125108
Keywords
Biological importance; chemistry; heterocycles; pharmacophores; spirooxindoles; synthesis
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Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities. Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.
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