Journal
JOURNAL OF EXPERIMENTAL NEUROSCIENCE
Volume 13, Issue -, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1179069519830697
Keywords
Frontotemporal dementia; amyotrophic lateral sclerosis (ALS); Alzheimer disease; tauopathy; repetitive elements; retrotransposons
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Funding
- NINDS [R01 NS063964]
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Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between neurodegeneration-associated proteins and derepression of repetitive element transcription due to changes in heterochromatin. We suggest that this derepression leads to an increased accumulation of intracellular double-stranded RNA (dsRNA), with an attendant induction of innate immune responses that contribute to the neuroinflammation found in essentially all age-associated neurodegenerative diseases.
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