Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 11, Pages 1548-1551Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc07461e
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Funding
- National Natural Science Foundation of China [U1605253, 81741008]
- Innovation Team Development Plan by the Ministry of Education of China [IRT 15R10]
- Special Funds of the Central Government Guiding Local Science and Technology Development [2017L3009]
- Ministry of Science and Technology (MOST), Taiwan [106-2113-M-002-025-MY2]
- National Taiwan University [107-L892802]
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A dual signal amplification method based on surface-enhanced Raman scattering (SERS) is developed by photo-triggered release of SERS probes from mesoporous silica-coated Au nanorods (SiO2@Au) and the use of a specially-designed SERS substrate with an internal reference. Two metal carbonyl (metal-CO) labels (Os-SCO and Re-SCO) are proposed here as novel interference-free labels. Results demonstrate that tumor-related DNA can be quantitatively detected by this reliable and ultra-sensitive SERS platform.
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