Journal
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
Volume 7, Issue 1, Pages 96-104Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/2050640618804443
Keywords
Endosonography; endoscopic ultrasound-guided tissue acquisition; fine-needle biopsy (FNB); pancreatic cancer; 20G ProCore (R); solid pancreatic neoplasm
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Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC 5 per mille grant) [12182]
- European Community FP7 Grant Cam-Pac [602783]
- Italian Federation of Family Paediatricians (FIMP)
- Ministero Salute [CUP_J33G13000210001]
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Background Innovative approaches to improve diagnostic yield of endoscopic ultrasound-guided tissue acquisition (EUS-TA) have focused on needle design with development of fine-needle biopsy (FNB) needles with microcore-acquisition technology. Recently, a 20-gauge (20G) antegrade-cutting-side-bevelled biopsy needle (ProCore (R)) was developed for EUS-TA, but data about its diagnostic performance and histological capability are scant. Objectives We assessed the diagnostic performance and histologic retrieval rate of a new 20G antegrade-cutting-side-bevelled biopsy needle compared with a 22G reverse-side-bevelled needle for EUS sampling of solid pancreatic lesions. Patients and methods A retrospective analysis of 238 consecutively collected patients who underwent EUS-TA using a 20G or a 22G ProCore (R) needle, without rapid on-site evaluation (ROSE), was conducted at two centres. Sensitivity, specificity, positive predictive value and negative predictive value were calculated. Histologic tissue retrieval was evaluated applying a scoring system for each case. Results Sensitivity and specificity were estimated as 98.4-100% in the 20G-, and 94.9-100% in the 22G-needle groups, respectively (p > 0.99). The 20G procured more histologic-grade tissues (92.6% vs 49.5%, p < 0.0001) achieved by a lower number of passes (2.64 vs 3.44, p < 0.0001) compared to the 22G. Conclusions Both side-bevelled FNB needles achieved a high diagnostic sensitivity. The 20G-side-bevelled needle obtained a significantly higher microcore retrieval rate.
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