Journal
ACS APPLIED BIO MATERIALS
Volume 2, Issue 2, Pages 625-629Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00751
Keywords
interfacial molecular beacon; surface plasmon coupled emission; fluorescence; graphene oxide; biochip
Funding
- National Natural Science Foundation of China [21375111, 21505109, 21874110, 21521004]
- 973 Program of China [2013CB933703]
- Ministry of Education of China [PCSIRT IRT_ 17R66]
- Natural Science Foundation of Guangdong [2016A030310373]
Ask authors/readers for more resources
Integrating probes and a substrate together, a fluorescence-enhanced interfacial molecular beacon (FEIMB) is demonstrated, based on directional surface plasmon coupled emission. Through this simple yet efficient interfacial modulation engineering to create an interfacial quencher (graphene oxide)enhancer (gold nanofilm) pair, the quenching-to-enhancing region of FEIMB can be actively tuned. Therefore, it provides a spatial match between signal transduction and interface-mediated bio-recognition switching. Via combination of strong quenching and efficient plasmonic coupling, a synergistically amplified signal-to-background ratio of >1000-fold has been achieved. FEIMBs have been employed in protein and DNA detection, creating a high-performance and universal chip-based plasmon-mediated fluorescence sensing platform.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available