Journal
DATA IN BRIEF
Volume 22, Issue -, Pages 647-657Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dib.2018.12.078
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Funding
- British Heart Foundation Clinical Research Training Fellowship [FS/12/87/29899]
- Agency for Science Technology and Research (A*STAR), Singapore
- King Saud University, Kingdom of Saudi Arabia
- Wellcome Trust Clinical Research Training Fellowship
- Raymond and Beverly Sackler Scholarship
- European Society of Organ Transplantation Junior Basic Science Grant
- Bioscience and Biotechnology Research Council
- National Institute of Health Research Cambridge Biomedical Research Centre
- NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation at the University of Cambridge
- NHS Blood and Transplant (NHSBT)
- Newcastle University
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This data is related to the research article entitled Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy (Harper et al., 2016) [2]. The data presented here focuses on the humoral autoimmune response triggered by transferred allogeneic CD4 T cells and includes details on: (a) the recipient splenic germinal center (GC) response; (b) augmentation of humoral autoimmunity and accelerated heart allograft rejection following transplantation from donors primed against recipient; (c) flow cytometric analysis of donor and recipient CD4 T cells for signature markers of T follicular helper cell differentiation; (d) in vitro donor endothelial cell migration in response to column purified autoantibody from recipient sera; (e) analysis of development of humoral responses in recipients following adoptive transfer of donor CD4 T cells and; (f) the development of humoral autoimmunity in mixed haematopoietic chimeric mice. (C) 2019 The Authors. Published by Elsevier Inc.
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