Journal
ELECTROANALYSIS
Volume 28, Issue 2, Pages 372-379Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201500329
Keywords
flutamide; irinotecan; voltammetry; pencil graphite electrode; drug analysis
Categories
Funding
- Alexander von Humboldt Stiftung, Germany
Ask authors/readers for more resources
A sensitive electrochemical method based on square wave cathodic adsorptive stripping voltammetry (SWCASV) using pencil graphite electrodes (PGE) was developed for the individual and simultaneous determination of the anticancer drugs flutamide (Flu) and irinotecan (Irino) in biological fluids. Calibration curves showed an excellent linear response with limits of detection of 1.68 x 10(-9) and 1.55 x 10(-8) M Irino and Flu, respectively. The statistical evaluation of within-day repeatability (n=5) and day to day precision (n=5) showed satisfactory accuracy and precision. SWCASV using a PGE for individual and simultaneous determination of both drugs in bulk form, human urine and serum samples was demonstrated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available