Journal
ELECTROANALYSIS
Volume 27, Issue 8, Pages 1855-1863Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201500107
Keywords
Multiwalled carbon nanotubes; Chitosan; Drug-DNA interactions; Electrochemical biosensors; Mitomycin C
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Funding
- TUBITAK [2210-C]
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A multiwalled carbon nanotubes (CNT)-chitosan (CHIT) modified pencil graphite electrode (CNT-CHIT/PGE) was developed for the first time herein for electrochemical monitoring of the interaction of an anticancer drug, mitomycin C (MC) and DNA. The characterization of unmodified PGE, CHIT/PGE, CNT/PGE and CHIT-CNT/PGE were performed by scanning electron microscopy and cyclic voltammetry techniques. The oxidation signals of MC and guanine were measured before and after interaction at the surface of CNT-CHIT/PGEs using differential pulse voltammetry. Electrochemical impedance spectroscopy technique was also successfully utilized for monitoring of the interaction process at the surface of CNT-CHIT/PGEs in different interaction times.
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