Journal
BIOMOLECULES
Volume 9, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/biom9010001
Keywords
microtubule dynamics; mitosis; spindle; molecular motor protein
Categories
Funding
- NIH [R35 GM122482]
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Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.
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