Journal
MICROPOROUS AND MESOPOROUS MATERIALS
Volume 249, Issue -, Pages 55-60Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micromeso.2017.04.042
Keywords
Metal-organic framework; pH; Temperature; Controlled release
Categories
Funding
- National Natural Science Foundation of China [51432001, 51472217, 51472067, 51632008, U1609219]
- Zhejiang Provincial Natural Science Foundation of China [LZ15E020001]
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A porous metal-organic framework Zn-TBDA (TBDA = 4'-(1H-tetrazol-5-yl) -[1,1'-biphenyl]-3,5-dicarboxylic acid) with one-dimensional channels has been synthesized from zinc ions and bifunctional ligands. The negligible cytotoxicity of Zn-TBDA is confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay and microscopy observation. The anticancer drug methotrexate (MTX) is loaded into Zn-TBDA successfully via in-situ encapsulation and the loading capability reaches about 12.59 wt in resulting composite MTX-encapsulated Zn-TBDA. Under different physiological microenvironments, MTX-encapsulated Zn-TBDA exhibits sensitive pH and temperature dual-responsive release manners, revealing its practical value as a smart drug carrier with controlled release in certain site and improved therapeutic efficacy without any additional external fields. (C) 2017 Elsevier Inc. All rights reserved.
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