Journal
MICRON
Volume 100, Issue -, Pages 34-37Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micron.2017.04.008
Keywords
Exosomes; Multivesicular bodies; Endosomes; Carabid beetles
Categories
Funding
- Ministero dell'Ambiente e della Tutela del Territorio e del Mare - Ente Parco Nazionale della Sila [2678, XIII/4]
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Exosomes in Malpighian tubules of Calathus fuscipes (Coleoptera: Carabidae) were investigated under transmission electron microscopy. Ultrastructural analyses showed a wide number of multivesicular bodies localized in the apical portion of epithelial cells. Each multivesicular body encloses from 15 to 80 intraluminal vesicles (about 50 nm in diameter), originating through inward budding of late endosomes that package molecules into luminal membrane-bound structures. Subsequently they are released as exosomes through exocytosis of multivesicular bodies into the extracellular space after fusion with plasma membrane. Our results are the base for further investigation on the role of exosomes in functional polarization of tubule cells and on cell-to-cell communication in insects.
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