Highly Sensitive Differential Pulse and Square Wave Voltammetric Methods for Determination of Strontium Ranelate in Bulk and Pharmaceutical Dosage Form

The voltammetric behavior of Strontium Ranelate (SR) was studied using Cyclic (CV), differential pulse (DPV) and square wave (SWV) voltammetry. CV showed two well-defined, irreversible, diffusion-controlled anodic peaks using Britton-Robinson buffer, pH 2.0 at Pencil graphite (PGE), Carbon paste (CPE) and glassy carbon (GCE) electrodes. The peak current-concentration relationship was rectilinear over the range 1.0-10.0, 1.0-11.25 and 2.5-24.0 mu g/mL at PGE, CPE and GCE respectively, with a minimum detectability of 0.17, 0.24 and 0.39 mu g/mL for peak 1 and 0.19, 0.27 and 0.51 mu g/mL for peak 2. Recoveries showed the high accuracy of the method; 99.8%, 99.5% and 99.7% at PGE, CPE and GCE respectively for peak 1 and 100.1%, 99.9% and 99.7% at PGE, CPE and GCE respectively for peak 2. Hence DPV and SWV were conducted for the quantitative determination of SR in its pure and pharmaceutical dosage form. the method was validated and the results were in good agreement with those obtained from the reported method.