Journal
CARDIOVASCULAR REVASCULARIZATION MEDICINE
Volume 20, Issue 1, Pages 38-42Publisher
ELSEVIER INC
DOI: 10.1016/j.carrev.2018.05.011
Keywords
Resistant hypertension; Renal denervation; Y-Pattern; Brachial approach
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Objectives: We assessed a novel approach to percutaneous renal denervation for uncontrolled hypertension consisting of ablation beyond the proximal main renal artery (Y-pattern), including the primary branches, and compared it to the standard procedure applied only within the main vessel. We also assessed the safety and practicality of a brachial access approach. Methods and results: Renal denervation was performed on 119 consecutive patients (60 +/- 13 years). In 68 of the patients, femoral arterial vascular approach was used and in 51 brachial. In 80 patients treated with the standard ablation, 12.0 +/- 3.0 total ablations (both sides) were applied while 20.4 +/- 3.9 total ablations were delivered for the group of 39 patients with lf-pattern denervation (P < 0.001). Technically successful renal denervation was achieved in all patients. Office blood-pressure levels at baseline were 170 +/- 17/93 +/- 10 mm Hg for the standard group and 169 +/- 13/96 +/- 9 mm Hg for the If-pattern group. No major adverse events occurred during the procedure or in the postprocedural in-hospital period. Renal denervation was associated with significant decreases in both office and ambulatory systolic and diastolic blood pressure in both groups. The reduction in 24-hour mean ambulatory systolic blood pressure at 6 months was significantly greater (P= 0.002) for the V-Pattern group (-22.1 +/- 15.4 mm Hg) compared to the Standard group (-11.8 +/- 16.2 mm Hg). Changes in diastolic office and ambulatory pressure were also significantly greater at 6 months in the Y-pattern ablation group. Indices of blood pressure variability improved in both groups. Conclusion: Renal denervation using a Y-pattern ablation strategy combined with a greater number of lesions is safe and resulted in significant greater decreases in mean 24-hour ambulatory systolic and diastolic blood pressure compared to the conventional approach in this single-centre matched cohort study. Brachial artery access was shown to be feasible and safe for renal denervation. (C) 2018 Elsevier Inc. All rights reserved.
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