Journal
ELECTROANALYSIS
Volume 27, Issue 11, Pages 2670-2678Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201500138
Keywords
Carbon paste electrodes; Copper; Differential pulse voltammetry; Electrochemistry; Flavonoids; Metal chelation
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Funding
- NSERC Discovery Grant
- Alzheimer Society of Canada
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The development of therapeutic compounds that can attenuate the toxicity exerted by the accumulation of metal ions has been an area of intensive research in neurodegenerative diseases. In this report, an electrochemical method was developed to determine the Cu(II)-chelating ability of polyphenols that were implicated in Alzheimer's disease (AD). The results suggested the strength of flavonoids to chelate Cu(II) as epigallocatechin-3-gallate (EGCG)> resveratrol> clioquinol> baicalein similar to scyllo-inositol. Furthermore, the number of hydroxyl groups was found to play a role to lower Cu(II) oxidation signal using differential pulse voltammetry.
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