Electroanalysis of Natural Compounds as Copper Chelating Agents for Alzheimer's Disease Therapy

The development of therapeutic compounds that can attenuate the toxicity exerted by the accumulation of metal ions has been an area of intensive research in neurodegenerative diseases. In this report, an electrochemical method was developed to determine the Cu(II)-chelating ability of polyphenols that were implicated in Alzheimer's disease (AD). The results suggested the strength of flavonoids to chelate Cu(II) as epigallocatechin-3-gallate (EGCG)> resveratrol> clioquinol> baicalein similar to scyllo-inositol. Furthermore, the number of hydroxyl groups was found to play a role to lower Cu(II) oxidation signal using differential pulse voltammetry.