Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 6, Issue 4, Pages 493-497Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo01204k
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Funding
- National Natural Science Foundation of China [21402194]
- CAS Center of Excellence in Molecular Science, Chinese Academy of Sciences
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A highly effective and straightforward method for the construction of 2,3-unsubstituted benzofurans and benzothiophenes by the intramolecular Friedel-Crafts reaction has been developed. This phosphoric acid-catalyzed method exhibits good functional group tolerance for both electron-withdrawing groups and electron-donating groups. We have successfully obtained benzofuran and benzothiophene derivatives with various substituents, and the yield was up to 94%. The development of this reaction provides a simple and efficient strategy for the construction of benzofuran and benzothiophene skeleton compounds.
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