Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 13, Pages 1955-1958Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc10311a
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Funding
- National Natural Science Foundation of China [81622047, 81503201, 21572029]
- Distinguished Professor of Liaoning Province program
- State Key Laboratory of Fine Chemicals [KF1803]
- Royal Society
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We report an enzyme-activated fluorescence based probe (NHPO) for the selective detection of N-acetyl-b-D-glucosaminidase (NAG) activity in a drug-induced kidney injury mice model and NAG level in crude human urine. We used NHPO to explore the biological functions of NAG and provide a reference for the prognosis and prediction of proximal renal tubular dysfunction associated with various kidney diseases.
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