Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 13, Pages 1923-1926Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc09325c
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Funding
- European Research Council (ERC) under the European Union [772027 - SPICE - ERC-2017-COG]
- Deutsche Forschungsgemeinschaft [SFB 969]
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We report site-directed protein spin labelling via Suzuki-Miyaura coupling of a nitroxide boronic acid label with the genetically encoded amino acid 4-iodo-L-phenylalanine. The resulting spin label bears a rigid biphenyl linkage with lower flexibility than spin label R1. It is suitable to obtain defined electron paramagnetic resonance distance distributions and to report protein-membrane interactions and conformational transitions of alpha-synuclein.
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