Journal
MICROCHIMICA ACTA
Volume 185, Issue 1, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-017-2603-7
Keywords
MnO2 nanosheets; Mesoporous silica; Personal glucose meter; Glutathione; Portable detection; Target induced release
Categories
Funding
- National Natural Science Foundation of China [21775089, 21375076, 21705151]
- Project of Shandong Province Science and Technology Program [2015GSF121031]
- Outstanding Youth Foundation of Shandong Province [ZR2017JL010]
- Project of Beijing National Science Foundation [2174085]
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The authors describe a novel method for the determination of glutathione (GSH). Detection is based on target induced release of glucose from MnO2 nanosheet-gated aminated mesoporous silica nanoparticles (MSNs). In detail, glucose is loaded into the pores of MSNs. Negatively charged MnO2 nanosheets are assembled on the MSNs through electrostatic interactions. The nanosheets are reduced by GSH, and this results in the release of glucose which is quantified by using a commercial electrochemical glucose meter. GSH can be quantified by this method in the 100 nM to 10 mu M concentration range, with a 34 nM limit of detection.
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