Journal
MICROBIOLOGY-SGM
Volume 163, Issue 8, Pages 1145-1147Publisher
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.000499
Keywords
Candida albicans; pathogenesis; Medical Mycology; morphogenesis; immune response; drug resistance
Categories
Funding
- Wellcome Trust [086827, 075470, 101873, 200208]
- MRC Centre for Medical Mycology [N006364/1]
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Candida albicans is normally a harmless commensal of human beings, but it can cause superficial infections of the mucosa (oral/vaginal thrush) in healthy individuals and (rarely) infections of the skin or nails. It can also become invasive, causing life-threatening systemic and bloodstream infections in immunocompromised hosts, where the mortality rate can be as high as 50 %. It is the most common cause of serious fungal infection and is a common cause of nosocomial infections in hospitals. Some strains have been recognized that are resistant to azoles or echinocandins, which are the first-line antifungals for treatment of C. albicans infections.
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