Journal
AGING AND DISEASE
Volume 10, Issue 1, Pages 190-196Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2018.0224
Keywords
Hypothyroidism; Endometrial cancer; Sex hormone; Metabolic syndrome; Fertility
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Funding
- National Key Technology RD Program [2015BAI13B06]
- National Natural Science Foundation of China [81672571]
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Thyroid dysfunction is involved in several types of carcinoma. Hypothyroidism is one of the most common medical morbidities among patients with endometrial cancer; however, the related mechanism is unclear. Among the risk factors related to endometrial cancer, hypothyroidism interacts with metabolic syndrome, polycystic ovarian syndrome and infertility or directly acts on the endometrium itself, which may influence the development and progression of endometrial cancer. We summarize recent studies on the relationship between hypothyroidism and endometrial cancer and its risk factors to provide references for basic research as well as for clinical treatment and prognostic evaluation.
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