Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 3, Pages 467-471Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob02290a
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Funding
- Biotechnology and Biological Sciences Research Council South-West Doctoral Training Partnership (SWBio) [BB/J014400/1]
- European Research Council
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Heme plays a vital role in cell biology and dysregulation of heme levels is implicated in a wide range of diseases. However, monitoring heme levels in biological systems is currently not straightforward. A short synthetic peptide probe containing 7-azatryptophan is shown to bind hemin in vitro with quenching of the azatryptophan fluorescence. This chemical tool can be used to detect the change in free heme induced in human skin cells upon exposure to UVA irradiation.
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