Journal
MICROBIAL PATHOGENESIS
Volume 110, Issue -, Pages 359-364Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2017.07.022
Keywords
Whole genome sequencing; RNA-seq; Cronobacter sakazakii s-3; pmrA gene
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Funding
- National Key Research and Development Program of China [2016YFD04012021]
- Guangdong Special Support Program [2016TQ03N682]
- Pearl River SAMP
- T Nova Program of Guangzhou [201710010061]
- Science and Technology Planning Project of Guangdong Province
- National Outstanding Doctoral Dissertation Funding [201459]
- Fundamental Research Funds for the Central Universities [2017ZD092]
- Open Research Fund of State Key Laboratory of Biological Fermentation Engineering of Beer [K2017001]
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Cronobacter sakazakii is a well-known opportunistic pathogen responsible for necrotizing enterocolitis, meningitis and septicaemia in the premature, immunocompromised infants and neonates. This pathogen possesses various virulence factors and regulatory systems, and pmrA/pmrB regulatory system has been identified in a variety of bacterial species. The current study aims to investigate role of pmrA gene in the pathogenicity and virulence characteristics of Cronobacter sakazakii using whole genome sequencing and RNA-seq. Results demonstrated that the absence of pmrA has the potential to affect Cronobacter sakazakii on its pathogenicity, virulence and resistance abilities by regulating expression of numerous related genes, including CusB, CusC, CusR and ESA_pESA3p05434. (C) 2017 Elsevier Ltd. All rights reserved.
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