Journal
MICROBIAL CELL FACTORIES
Volume 16, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s12934-017-0675-z
Keywords
Two-component regulatory system; Biosensor; Bioremediation; Genetic circuit; Biorefinery
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT, and Future Planning (MSIP) [NRF- 2015R1A2A2A01004733]
- Golden Seed Project - Ministry of Oceans and Fisheries [213008-05-1-SB910]
- Mid-career Researcher Program from MSIP through NRF of Korea [NRF-2016R1A2B4008707]
- Institute of Planning & Evaluation for Technology in Food, Agriculture, Forestry & Fisheries (iPET), Republic of Korea [213008051SB910] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [22A20130012880, 2016R1A2B4008707] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Two-component regulatory systems (TCRSs) mediate cellular response by coupling sensing and regulatory mechanisms. TCRSs are comprised of a histidine kinase (HK), which serves as a sensor, and a response regulator, which regulates expression of the effector gene after being phosphorylated by HK. Using these attributes, bacterial TCRSs can be engineered to design microbial systems for different applications. This review focuses on the current advances in TCRS-based biosensors and on the design of microbial systems for bioremediation and their potential application in biorefinery.
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