Journal
RESPIRATORY INVESTIGATION
Volume 57, Issue 2, Pages 111-121Publisher
ELSEVIER
DOI: 10.1016/j.resinv.2018.11.005
Keywords
Emphysema; Cigarette smoke; Mutations; Oxidative stress; Nucleotide excision repair
Categories
Funding
- American Cancer Society [128511-MRSG-15-163-01-DMC]
- Showalter Research Foundation
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Cigarette smoking is the leading cause of lung cancer and chronic obstructive pulmonary disease (COPD). Many of the detrimental effects of cigarette smoke have been attributed to the development of DNA damage, either directly from chemicals contained in cigarette smoke or as a product of cigarette smoke-induced inflammation and oxidative stress. In this review, we discuss the environmental, epidemiological, and physiological links between COPD and lung cancer and the likely role of DNA damage and repair in COPD and lung cancer development. We explore alterations in DNA damage repair by DNA repair proteins and pathways. We discuss emerging data supporting a key role for the DNA repair protein, xeroderma pigmentosum group C (XPC), in cigarette smoke-induced COPD and early lung cancer development. Understanding the interplay between cigarette smoke, DNA damage repair, COPD, and lung cancer may lead to prognostic tools and new, potentially targetable, pathways for lung cancer prevention and treatment. (C) 2018 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.
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