Journal
METALLOMICS
Volume 9, Issue 7, Pages 876-890Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7mt00152e
Keywords
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Categories
Funding
- NIH
- NSF
- National Cancer Institute [P30CA023108]
- Department of Energy (DOE) - Geosciences [DE-FG0292ER14244]
- DOE [DE-AC0298CH10886]
- U.S. Department of Energy - Geosciences [DE-FG02-92ER14244]
- Brookhaven National Laboratory Department of Environmental Sciences
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC0298CH10886, DE-AC0276SF00515]
- DOE Office of Biological and Environmental Research
- National Institutes of Health, National Institute of General Medical Sciences [P41GM103393]
- U.S. DOE [DE-AC0206CH11357]
- US National Science Foundation [DBI 0701119, IOS-0919941]
- US National Institutes of Health [R01GM078536]
- US Department of Energy [DE-FG-2-06ER15809]
- US National Institute of Environmental Health Sciences [P42 ES007373]
- NSF Plant Genome grant [DBI 0701119]
- National Science Foundation Graduate Research Fellowship
- Sigma Delta Epsilon-Graduate Women in Science
- Dartmouth Graduate Alumni Research Award
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Iron (Fe) is required for plant health, but it can also be toxic when present in excess. Therefore, Fe levels must be tightly controlled. The Arabidopsis thaliana E3 ligase BRUTUS (BTS) is involved in the negative regulation of the Fe deficiency response and we show here that the two A. thaliana BTS paralogs, BTS LIKE1 (BTSL1) and BTS LIKE2 (BTSL2) encode proteins that act redundantly as negative regulators of the Fe deficiency response. Loss of both of these E3 ligases enhances tolerance to Fe deficiency. We further generated a triple mutant with loss of both BTS paralogs and a partial loss of BTS expression that exhibits even greater tolerance to Fe-deficient conditions and increased Fe accumulation without any resulting Fe toxicity effects. Finally, we identified a mutant carrying a novel missense mutation of BTS that exhibits an Fe deficiency response in the root when grown under both Fe-deficient and Fe-sufficient conditions, leading to Fe toxicity when plants are grown under Fe-sufficient conditions.
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