Journal
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 49, Issue 3, Pages 1284-1288Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-018-3808-2
Keywords
Cannabidiol; Medical cannabis; Medical marijuana; Autism spectrum disorder; Disruptive behavior
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Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age=11.8 +/- 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). One girl who used higher tetrahydrocannabinol had a transient serious psychotic event which required treatment with an antipsychotic. Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients. This preliminary study supports feasibility of CBD-based cannabis trials in children with ASD.
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