Journal
MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 112, Issue 8, Pages 572-576Publisher
FUNDACO OSWALDO CRUZ
DOI: 10.1590/0074-02760170054
Keywords
TERRA; Trypanosoma brucei telomere; Leishmania telomere; telomere transcription
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Funding
- FAPESP [14/06824-8, 07/54504-9, 13/00570-1]
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [AI028798, AI110325]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/00570-1] Funding Source: FAPESP
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The Telomeric Repeat- containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.
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