Journal
ENDOCRINOLOGY
Volume 160, Issue 1, Pages 81-100Publisher
OXFORD UNIV PRESS INC
DOI: 10.1210/en.2018-00591
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Funding
- National Institutes of Health (NIH) National Heart, Lung, and Blood Institute [HL071981, HL034594, HL126024]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK115679, DK091718, DK100383, DK078616]
- Boston Obesity Nutrition Research Center [DK46200]
- United States-Israel Binational Science Foundation [2011036]
- American Heart Association Scientist Development Award [0730094N]
- Japan Society for the Promotion of Science
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Obesity and abdominal obesity have been closely related to cardiovascular outcomes, and recent evidence has indicated that environmental and genetic factors act in concert in determining the risks of these conditions. Improving adherence to healthy lifestyle habits and healthy dietary patterns can at least partly counteract genetic variations related to risks of obesity and cardiovascular disease (CVD). Other factors, such as epigenetic alterations, may also modulate a relationship between genetic susceptibility and these disorders. In this review, we highlight data from recent studies on gene and environmental risk factors for obesity and CVD, and describe how these findings might inform understanding of the complex roles of interactions between genes and environmental factors in the development of obesity and CVD.
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