4.7 Article

A lysosome-targeting dual-functional fluorescent probe for imaging intracellular viscosity and beta-amyloid

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 18, Pages 2688-2691

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc00113a

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Funding

  1. Natural Science Foundation of Guangdong Province, China [2016A030310463, 2016A010121004]
  2. National Natural Science Foundation of China [21502056]
  3. Medical Scientific Research Foundation of Guangdong Province, China [A2018080]

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A lysosome- targeting dual-functional fluorescent probe was rationally designed and developed for imaging intracellular lysosomal viscosity and beta-amyloid. More importantly, the real-time tracking of the dynamic movement of lysosomes, as vesicle structures, has been achieved using Lyso-MC.

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