4.6 Article

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Journal

MATERIALS HORIZONS
Volume 6, Issue 2, Pages 385-393

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8mh01145a

Keywords

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Funding

  1. Chinese Scholarship Council
  2. Orion Research Foundation
  3. Jane and Aatos Erkko Foundation [4704010]
  4. Academy of Finland [297580]
  5. Sigrid Juselius Foundation [28001830K1, 4704580]
  6. Ministry of Science and Technology [2017YFA0504504, 2016YFA0502001]
  7. National Natural Science Foundation of China [81422045, U1405223, 81661138005]
  8. Fundamental Research Funds for the Central Universities of China [20720160064]
  9. Program of Introducing Talents of Discipline to Universities (111 Project) [B12001]
  10. University of Helsinki Funds
  11. HiLIFE Research Funds
  12. European Research Council under the European Union [310892]

Ask authors/readers for more resources

Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

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