Journal
REACTION CHEMISTRY & ENGINEERING
Volume 4, Issue 2, Pages 244-253Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8re00225h
Keywords
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Funding
- UGC India [(BRNS-37.2)/14/06/2018]
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1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) has emerged as an attractive tool in developing and facilitating C-H activation/functionalizations. The hydrogen bond donating ability of this solvent coupled with its enhanced acidity and reduced nucleophilicity has played an integral part in boosting the reactivity and stereoselectivity of C-H functionalization reactions. Several C-H activation reactions necessitate the requirement of HFIP which plays a central role in developing these methodologies. Herein, this report showcases the importance of HFIP in developing C-H activation reactions in organic synthesis.
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