Journal
AMERICAN JOURNAL OF CANCER RESEARCH
Volume 9, Issue 2, Pages 219-227Publisher
E-CENTURY PUBLISHING CORP
Keywords
Cancer; cholesterol; metabolism; oncogenic signaling
Categories
Funding
- Foundation of Xinqiao Hospital [2016D417]
- National Natural Science Foundation of China [81801369]
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Cholesterol plays an important role in cancer development. Both clinical and experimental studies have found that hypercholesterolemia and a high-fat high-cholesterol diet can affect cancer development. External cholesterol can directly activate the oncogenic Hedgehog pathway, and internal cholesterol can induce mTORC1 signaling. Cholesterol is a key component of lipid rafts, which are the major platforms for signaling regulation in cancer, and chelating membrane cholesterol is an effective anti-cancer strategy that disrupts the functions of lipid rafts. Cholesterol metabolism is often reprogrammed in cancer cells. Targeting cholesterol metabolism as a new therapeutic approach has received increasing attention. Here, we summarize some key molecular mechanisms supporting the use of anti-cholesterol therapy for cancer treatment.
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