Journal
CHEMICAL SOCIETY REVIEWS
Volume 48, Issue 4, Pages 1077-1094Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cs00395e
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Funding
- Georgia State University
- Brains & Behavior fellowship
- Center for Diagnostics and Therapeutics fellowship
- Molecular Basis of Disease fellowship
- Georgia Research Alliance endowment established at Georgia State University
- 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University [ZYJC18032, ZY2016101, ZY2016203]
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Prodrug approaches represent an excellent solution to certain pharmaceutical issues commonly encountered in the drug discovery and development process. Along this line, the chemistry needed for the bio-reversible derivatization of drug functional groups for on-demand release is critical. In recent years, click and release approaches have shown great promise in the design of prodrugs because of their bioorthogonality and controlled bond-cleavage, which help ensure prodrug stability during circulation and ready cleavage at the desired site of action. This review highlights recent developments of this research field and discusses issues yet to be addressed.
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