Systemic immune-inflammation index (SII) is a useful prognostic indicator for patients with squamous cell carcinoma of the esophagus

The aim of the study was to determine the prognostic role of systemic immune-inflammation index (SII) in patients with esophageal squamous cell carcinoma (ESCC). A total of 298 ESCC patients were enrolled in the current retrospective study. The SII was calculated by the formula: neutrophil x platelet/lymphocyte. The optimal cut-off value was calculated by the Cutoff Finder. Univariate and multivariate analyses were evaluated for cancer-specific survival (CSS). Additional, we also established a nomogram model to predict the prognosis for patients with ESCC. The optimal cut-off value was 410x10(9)/L for SII. Patients with SII <410(x10(9)/L) had a significantly better 5-year CSS than patients with SII > 410(x10(9)/L) (51.9% vs 24.0%, P< 0.001). Multivariate analyses revealed that SII was a significant independent predictive indicator (P= 0.027). A nomogram could be more accuracy for CSS for patients with ESCC (c-index: 0.68). The SII is a useful independent prognostic indicator for patients with resectable ESCC.