Journal
MEDICINE
Volume 96, Issue 4, Pages -Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000005886
Keywords
cancer-specific survival (CSS); esophageal squamous cell carcinoma (ESCC); neutrophil to lymphocyte ratio (NLR); platelet to lymphocyte ratio (PLR); prognosis
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The aim of the study was to determine the prognostic role of systemic immune-inflammation index (SII) in patients with esophageal squamous cell carcinoma (ESCC). A total of 298 ESCC patients were enrolled in the current retrospective study. The SII was calculated by the formula: neutrophil x platelet/lymphocyte. The optimal cut-off value was calculated by the Cutoff Finder. Univariate and multivariate analyses were evaluated for cancer-specific survival (CSS). Additional, we also established a nomogram model to predict the prognosis for patients with ESCC. The optimal cut-off value was 410x10(9)/L for SII. Patients with SII <410(x10(9)/L) had a significantly better 5-year CSS than patients with SII > 410(x10(9)/L) (51.9% vs 24.0%, P< 0.001). Multivariate analyses revealed that SII was a significant independent predictive indicator (P= 0.027). A nomogram could be more accuracy for CSS for patients with ESCC (c-index: 0.68). The SII is a useful independent prognostic indicator for patients with resectable ESCC.
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