Journal
MEDICINE
Volume 96, Issue 49, Pages -Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000009034
Keywords
caffeine; green tea polyphenols; meta-analysis; osteoporosis; tea
Categories
Funding
- National Natural Science Foundation of Jiangsu Province [BK20160735]
- Earmarked Fund for Modern Agro-industry Technology Research System [CARS-23]
- National Natural Science Foundation of China [31570689]
- Postdoctoral Science Foundation of Jiangsu Province [1601078C]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Background: Previous reports have suggested a potential association of tea consumption with the risk of osteoporosis. As such association is controversial, we conducted a meta-analysis to assess the relationship between tea consumption and osteoporosis. Methods and Findings: We systematically searched PubMed, EMBASE and WanFang databases until March 30, 2016, using the keywords tea and osteoporosis, without limits of language. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were derived by using random-effects models throughout the analyses. We conducted the analysis of the statistical heterogeneity using Cochrane I-2. The funnel plot was used to speculate the publication bias, while the subgroup analysis and multiround elimination method were employed. Results: Our study was based on 17 journal articles, including 2 prospective cohort studies, 4 case-control studies, and 11 cross-sectional studies. In the present study, the total OR of osteoporosis for the highest versus the lowest categories of tea consumption was 0.62 (95% CI, 0.46-0.83), with significant heterogeneity among studies (I-2=94%, P <.01). There was, however, no publication bias of the meta-analysis about tea consumption and osteoporosis. Subgroup analysis showed that tea consumption could reduce the risk of osteoporosis in all examined subgroups. Conclusion: In the present study, it can be concluded from the results that tea consumption can reduce the risk of osteoporosis.
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