Journal
GLOBAL CHALLENGES
Volume 3, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/gch2.201800058
Keywords
anticancer; charge transfer; functional coatings and films; mitochondria; vanadium dioxide
Categories
Funding
- Alexander von Humboldt Stiftung/Foundation
- National Natural Science Foundation of China [31370957]
- Hong Kong Research Grant Council General Research Funds [CityU 11301215, HKU 718913, N_HKU726-16, 17214516]
- City University of Hong Kong Donation Research Grant [9220061]
- City University of Hong Kong Applied Research Grant [9667144]
- ITF Projects [ITS/287/17, GHX/002/14SZ]
- Hong Kong Health and Medical Research Fund [03142446]
- Shanghai Sailing Program [17YF1429800]
- Sanming Project of Medicine in Shenzhen Team of Excellence in Spinal Deformities and Spinal Degeneration Diseases [SZSM201612055]
- Shenzhen Science and Technology Research Funding [JCYJ20160429190821781, JCYJ20160429185449249]
- Guangdong Scientific Plan [2014A030313743]
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A biomaterials surface enabling the induction of tumor cell death is particularly desirable for implantable biomedical devices that directly contact tumor tissues. However, this specific antitumor feature is rarely found. Consequently, an antitumor-cell nanocoating comprised of vanadium dioxide (VO2) prepared by customized reactive magnetron sputtering has been proposed, and its antitumor-growth capability has been demonstrated using human cholangiocarcinoma cells. The results reveal that the VO2 nanocoating is able to interrupt the mitochondrial electron transport chain and then elevate the intracellular reactive oxygen species levels, leading to the collapse of the mitochondrial membrane potential and the destruction of cell redox homeostasis. Indeed, this chain reaction can effectively trigger oxidative damage in the cholangiocarcinoma cells. Additionally, this study has provided new insights into designing a tumor-cell-inhibited biomaterial surface, which is modulated by the mechanism of mitochondria-targeting tumor cell death.
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