Journal
ACS APPLIED BIO MATERIALS
Volume 2, Issue 3, Pages 975-980Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00783
Keywords
interpenetrating networks; neural stem cells; astrocytes; microglia
Funding
- Alzheimer's Association [AARGD-17-531470]
- Alzheimer's Texas [AARGD-17-531470]
- Trinity University Murchison research fellowship
- Trinity University start up fund
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This work describes for the first time the fabrication and characterization of multicomponent interpenetrating networks composed of collagen I, hyaluronic acid, and poly(ethylene glycol) diacrylate for the 3D culture of human neural stem cells, astrocytes, and microglia. The chemical composition of the scaffolds can be modulated while maintaining values of complex moduli within the range of the mechanical performance of brain tissue (similar to 6.9 kPa) and having cell viability exceeding 84%. The developed scaffolds are a promising new family of biomaterials that can potentially serve as 3D in vitro models for studying the physiology and physiopathology of the central nervous system.
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